NSTIM.com
nSIM
Neurostimulation Induced Medicine
Introducing a new neurophysiology
control system.
NSTIM is developing new ways to integrate signals of the parasympathetic nervous system with the brain. Our technology is designed to trigger life-saving neuroprotection mechanisms on demand using therapeutic electrical stimulation. In its first-generation, the nSIM devices are fit for use during surgery.
Innovative Technology to Advance Stroke Care
Stimulating Cranial Connections for Neuroprotection
At NSTIM, we are engineering a novel neuromodulation system intended to provide protective electrical stimulation during acute stroke care.
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The devastating long-term debilitation caused by stroke registers over ~140,000 deaths and more than 185,000 recurrent strokes cases in the U.S. alone yearly. The majority of the stroke survivors remain severely attached to the rehabilitation care system. Management of the brain’s physiologic and metabolic crisis is largely ineffective due to the blunt and fluctuating nature of medications. Importantly, many homeostatic functions of the brain and peripheral organs are programmed within the autonomic nervous system become naturally deregulated after injury.
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Electrical stimulation is reportedly neuroprotective, outcompeting pharmacological approaches and ultimately leading to reduced stroke volume and neural injury.
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We designed a new functional neurostimulation device that fits seamlessly within the standard-of-care for severe stroke because it is pre-embedded on the patient intubation accessories - the nSIM device. nSIM delivers controlled functional stimulation through the recurrent laryngeal nerve non invasively.
nSIM Therapy stands for neuro stimulation-induced molecular therapy, a novel neuroprotective approach.
NSTIM has an incredible team with expertise in neurosciences, molecular medicine, medical physics, biomedical engineering and neurosurgery. The company founders are a talented team of scientists, physicians and engineers.  Read below to learn more about the incredible NSTIM llc team.
Tatiana Wolfe
Co-Founder & Inventor
Dr. Tatiana Wolfe is a medical physicist imaging scientist with over a decade of experience in neurotechnology. Dr. Wolfe holds expertise in neurophysics and translational medical sciences, with remarkable experience in signal processing and modeling for diagnostics and therapy. Dr. Wolfe is focused on the execution of NSTIM's primary mission to design a transformative stimulation control system to deliver neuroprotective therapy intelligently.
Philip J. Horner
Co-Founder & Scientific Advisor
Dr. Horner is a neuroscientist who has conducted pioneering research in mechanism of neural plasticity in the injured nervous system. Dr. Horner received a Ph.D. in physiology from Ohio State University in 1995. In 2001, Dr. Horner joined the faculty of the Department of Neurological Surgery at the University of Washington in Seattle. He directed a laboratory at the UW South Lake Union Campus and was a member of the Institute for Stem Cell and Regenerative Medicine. Dr. Horner is currently the Scientific Director of the Center for Neuroregeneration, Vice Chairman, Research, Department of Neurosurgery, Professor and Full Member of the Houston Methodist Research Institute. Dr. Horner is a member of the Program in Neuroscience at Weill Cornell Graduate School and is co-Director of NeuralCODR Training Program at Houston Methodist Research Institute. Dr. Horner focuses on the experimental design and validation of NSTIM technology and brings experience in pre-clinical models of neural injury and rigorous, scientific assessment of brain plasticity.
Gavin W. Britz
Co-Founder & Scientific Advisor
Dr. Britz is a neurosurgeon with 30 years’ experience in the acute management of stroke and sub-arachnoid hemorrhage. Dr. Britz brings expertise in clinical trials in the acute neurologic care setting and neurosurgery. Dr. Britz is one of the original nSIM inventors.
Britz is responsible for the rigor of surgical feasibility testing and human modeling. Dr. Britz is guiding device system design advancements and device-user interface software from the perspective of the user.
Hemang Trivedi
Co-Founder & Leading Technology Advisor
Hemang Trivedi is one of the founding members of NSTIM. As the Chief Technology Officer, he is leading the overall product development, preclinical/clinical validation studies and other engineering-related tasks to develop NSTIM's novel neuromodulation system. He is also directing the development of innovative technologies for next generation of the current system. He has training and hands-on experience in R&D, manufacturing and quality management of medical devices. He has driven the proof-of-concept & early feasibility studies of the device and currently working on translating the technology to clinic.
Hemang has a Master's degree in Biomedical Engineering from University at Buffalo - SUNY and Bachelor's degree in Biomedical Engineering from University of Mumbai.
Kristopher Hoffman
Technology Engineer Advisor
Kristopher Hoffman is a Mechanical Engineer in the Center for Neuroregeneration in the Houston Methodist Research Institute and partner at NSTIM. Mr. Hoffman has over a decade of experience in system engineering and recent training in translational medicine research. Mr. Hoffman has particular interest in the development of control systems and neurointerface software for medical devices. At the Houston Methodist Hospital’s Center for Neuroregeneration, he has learned extensively about nerve stimulation and electrophysiology in both small and large vertebrate models, and is currently pursuing further cross-disciplinary experience in the specific field of stroke. This one-of-a-kind interdisciplinary experience has expanded his vision as he grows to complete his degree in Engineering. Mr. Hoffman is the project engineer at NSTIM for development and optimization of the neuroprotective control system interface. He contributes to the development and translational tests of the nSIM device by working directly to build an intuitive user interface that allows for therapeutic protocol delivery in vivo, as well as contribute to data analytics, scientific dissemination and proactively promote interaction between NSTIM and Dr Philip Horner’s team.
Vision
Brain stability to minimize injury: a neuroelectrical molecular approach
At NSTIM, we work to design new neurofunction modulators, enabling direct access to the brain's survival control center. We envision that our technologies can positively impact health care for millions of patients during critical surgery stages while neuroprotecting human life.
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Developments
Clinical Partners
Research
Neuroscientist and world renowned expert in human electrostimulation therapeutics, Dr. Dimitry Sayenko, MD/PhD, is a valued NSTIM clinical partner. We work with Dr. Sayenko in the research for identifying neuroelectric phenotypes of regenerating function during rehabilitation therapy.
Medical Research Centers
Center for Neuroregeneration
Houston Methodist Research Institute
Learn more.
Business Development Partners
Investment
The Texas Medical Center environment for medical technology business is our rich ground.
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Innovation
nSIM: Neurostimulation Induced Medicine was invented by our team of scientists in 2017.
Learn more about it here.
Brain Control Regained During Surgery
At NSTIM, we are working to optimize functional neuroprotective stimulation during acute stroke care and beyond, ultimately aiming to spare brain damage in all patients in need of surgery.